Anti-angiogenesis targeted therapy in combination with chemotherapy is one of the limited options for systemic therapy beyond second line for patient with Ras mutant metastatic colorectal cancer. Aflibercept is an antiangiogenic therapy which improved survival for metastatic colorectal cancer with FOLFRI as a second line after failure of oxaliplatin containing regimen and can be used after failure of use of FOLFOX, or after failure of chemotherapy combination with bevacizumab, other options of antiangiogenic therapies include regorafenib or bevacizumab beyond disease progression. In this case report, the patient is a 53 years old male who had a multiple line of therapies for metastatic colorectal cancer (mCRC), including bevacizumab in combination with FOLFRI. He had complete remission confirmed by PET-CT after 6th cycle of aflibercept in combination with FOLFRI and reached progression free survival of eleven months. Aflibercept in combination with FOLFRI can give adequate Progression Free Survival (PFS) as a treatment beyond second line for good responder patients. This finding needs further research work and investigations.
 

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