The aim of this study was to evaluate the stress distribution in the supporting bone of splinted inclined implants by 3D finite element stress analysis. A three dimensional edentulous mandibula was constructed. Four dental implants were placed in the inter-foraminal area; 4 different models were created by inclining the mesial two implants with 0, 5, 10, and 15 degrees. 90 N vertical and 180 N oblique loads were applied unilaterally to right canine. Also, 150 N oblique loads were applied to the incisors to simulate biting force. Maximum and minimum principle stresses in the cortical bone around implants were evaluated. For the first and the second loading conditions, the highest maximum principle stress was observed in the highest inclined models and the lowest stresses were observed in the control models. For the third loading condition the highest maximum principle were observed in the vertically placed model, whereas the maximum inclined implants had shown the lowest maximum principle stress values. In all loading conditions, the highest maximum stress values were observed at the cortical bone around the neck of the implant. The principle stress in the supporting bone, were affected by loading conditions and the direction of the loading.