Semaglutide injection with lifestyle intervention has been shown to be more effective than lifestyle modification alone. However, pharmacological intervention shows fewer side effects than bariatric surgery. This cross-sectional study was conducted among the general population in Saudi Arabia. A self-administered questionnaire was sent among the targeted population using an online survey. The questionnaire includes socio-demographic data (e.g., age, gender, marital status, etc.), general awareness about Semaglutide injection, and a 4-item questionnaire to measure the knowledge about Semaglutide. Of the 382 participants, 52.4% were males, and 44.8% were aged between 18 to 30  years old. The level of knowledge about Semaglutide injection was poor among 69.4%, while the rest had good knowledge (30.6%). The overall mean knowledge score was 1.62 (SD 1.26) out of 4 points. Younger participants, gender female, unmarried, unemployed, normal or underweight, aware of Semaglutide injection, previous usage of Semaglutide, satisfaction with Semaglutide, and knowledge about combined benefits (diabetes control and weight loss) of Semaglutide injections were the factors associated with increased knowledge score. The knowledge of the general population regarding Semaglutide injection was lacking. Younger female participants with normal body weight who were satisfied with Semaglutide were identified as the most significant users of Semaglutide injections. Further investigations are needed to extract more data about the general population's knowledge of Semaglutide injections.

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