In the present study, a systematic review of experimental research carried out by drug delivery systems that allow for drug release in which oligonucleotides are imbrued, such as small interfering-/micro ribonucleic acids, was conducted. The data obtained after an electronic database query with no language limitation were evaluated using statistical methods. Results were shown as frequency. There was no research found that described successfully imbrued oligonucleotides into drug delivery systems that could be used to prevent intervertebral disc degeneration. There is a high possibility that trial target therapies might have a positive effect on nucleus pulposus cell regeneration, which is damaged most in the disc during intervertebral disc degeneration; however, these designs, whose invitro release kinetics have been reported, need to be tested invivo in living subjects after they have been tested for surgical techniques to fill this gap in the literature.
 

Download Full Text - PDF