The Objectives of this study is to determine the frequency of clinical features of rheumatoid arthritis in males and females in local population of Karachi. A descriptive prospective was conducted in tertiary care hospital in Karachi from August 1, 2017 till February 28, 2018.Careful selection of patient based on their clinical presentation and initial laboratory workup for RA factor was done and treated on the line of Rheumatoid arthritis and followed up in OPD for response with treatment. A total of 1600 patients were enrolled for study. Total of 1438 patients participated in the study and 162 patients were lost to follow up after discharge from hospital. Females were found to be predominant as compared to males. Majority of sample size was found in age group 21-40 and 40-61 years of age. RA factor was found negative in most of cases. Rheumatoid arthritis is a heterogeneous disease with gender variability. Sex related factors influence disease activity and severity, it should be considered as treatment responses and side effects may vary in both. In our study predominantly females of reproductive and middle age group reported to have clinical symptoms but found to have negative laboratory results.
 

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