The unprecedented scale and potential to completely devastate the public health systems internationally has drawn attention to the COVID-19 pandemic. In recent years’, the interdisciplinary approach to health and infectious diseases has been less looked upon, especially the areas of anthropological dynamics and its effect on infectious disease pathogens. To this effect, this study aims at investigating the anthropological factors that influence the spread of the SARS-Co-V-2 virus in the Lusaka District of Zambia. From the cross-sectional data collected in two Lusaka compounds, we carried out an anthropological study through univariate and multivariate linear regression analysis. To do this, we conducted an analysis using a dependent variable “is COVID-19 a serious problem” as a measure for the spread of SARS-Co-V-2 virus. The study had five anthropological variables and other variables to evaluate participants’ knowledge on COVID-19. But the study reported only the significant variables after the full analysis. Applying a stepwise analysis, the study found four anthropological variables (Belief about COVID-19, attitude towards COVID-19 vaccine, Handwashing practice before COVID-19 and in the mist of COVID-19 pandemics) significant at univariate level and one anthropological variable (Beliefs about COVID-19) significant at multivariate level. Demographic and anthropological determinants have a significant effect on the spread of SARS-Co-V-2 virus
 

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