Keratoconus is a progressive haracte disorder in which corneal deformation is associated with stromal thinning and biomechanical weakening. In recent years, there has been significant scientific interest in corneal biomechanical properties for a better understanding of physiology and physiopathology in order to provide a proper diagnosis and treatment of the disease. This review aims to explain different methods for the characterization of corneal biomechanics in keratoconus, both in the laboratory and clinical setting. Until now, many studies describing the measurement of corneal biomechanical properties using Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (CorVis ST) devices have been performed and published. However, there has been an increasing development of new methods which allow a better understanding of the differences of corneal properties between some ocular pathologies and healthy corneas. Also, this review discusses the advantages and limitations using these instruments and techniques in the early detection of keratoconus. Further research is necessary in order to consolidate their diagnostic capabilities.