Colorectal cancers (CRC) are among the most prevalent types of cancers in the world and in Iran, wherein, the age of affliction is lower than Western countries. We studied the antimicrobial effect of the bismuth nanoparticles on Klebsiella pneumoniae carrying PKS gene. PKS encodes colibactin which makes colorectal cancers more probable. In the present study we identified and isolated the PKS carrier isolates through application of PCR. Subsequently, the antibacterial effects of the bismuth nanoparticles, along with antibiotics including tetracycline; ciprofloxacin, Norofloxacin, and metronidazole were investigated on bacterial isolates. Results show all isolates were sensitive to all applied antibiotics, however, they showed resistance to the bismuth nanoparticles. Analysis on the synergistic effect of the bismuth nanoparticles with the aforementioned antibiotics shows a synergistic effect, however, there was difference between bacterial isolates as well as the degree of synergism. Results obtained in this study indicate, compared to the antibiotics, the bismuth nanoparticles could be effective against digestive system’s infection to lower extents. As well, it could be effective in lowering the colorectal cancer in the individuals’ carrier for the isolates.
 

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