Obesity poses one of the most serious public health challenges of the 21st century. The present study aimed to assess the surgery duration, postoperative complications, and length of hospital stay. The present retrospective cross-sectional study was conducted in the Department of Orthopedics and Spine Division, College of Medicine, King Khalid University Hospital, during the period January 2016 to July 2019. This study evaluated the data of patients with spondylolisthesis who underwent transforaminal lumbar interbody fusion (TLIF) at this tertiary hospital. We recruited adult patients with grade II degenerative spondylolisthesis who were admitted electively for transforaminal lumbar interbody fusion (TLIF). There were Sixty-nine patients included, of whom thirty eight were obese. The encountered complications were wound infection and deep venous thrombosis in two and three patients respectively. Seven patients had suboptimal wound healing. None of the patients developed pulmonary embolism or deep infection. Moreover, two patients needed readmission and reoperation with wound irrigation, debridement, and closure. The surgery duration was the only dependent variable that showed a substantial increase in the odds ratio among obese patients. The surgery duration was significantly longer when operating on obese patients. However, obesity was not associated with higher rates of postoperative complications or increased hospital stay.