Sulphadoxine pyrimethamine treatment has proven efficacious in reducing the burden of malaria associated with pregnancy. This study was undertaken to assess the compliance rate of pregnant women and its effectiveness on pregnancy in University of Calabar Teaching Hospital, Calabar. To give this study a focus, two(2) specific objectives were formulated; two research questions and two research hypothesis were generated based on the stated objectives. The population was 5500 and a sample size of 904 was used for the study, data were analyzed using descriptive statistics in form of percentage calculations. Each of the hypotheses was tested at 0.05 level of significance at 99df. The findings revealed that there was a significant relationship between intermittent preventive therapy and compliance rate of pregnant women to SP. There was a significant relationship between intermittent preventive therapy and level of occurrence of malaria on pregnant women. There was a significant relationship between intermittent preventive therapy and extent of malaria resistance on women using IPT/SP. It was therefore concluded that, the compliance rate to IPT among pregnant women is high. Based on those findings proper record keeping, provision of SP as an antenatal package, provision of facilities of proper implementation of IPT, proper supervision and administration of SP at 16 weeks might go a long way to enhance compliance and effectiveness to Intermittent preventive therapy IPT.
 

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