The adrenal gland and the brain are one of the most common sites for metastasizing of lung carcinoma, but this rarely occurs within a long time interval. Presenting a 58-year female patient with demonstrated right-lung adenocarcinoma (pT1N1M0), subjected to radical resection and adjuvant chemotherapy. After 40 months the patient was adrenalectomized due to a metastasis in the contralateral adrenal gland. Nine months after that a brain metastasis was established, and resection followed by chemotherapy was performed, to a good outcome. This is a case of development of metachronous single metastases into the adrenal gland and the brain after a long disease-free interval (the time interval from the pulmonary resection until the occurrence of a metastasis), as well as of high survival rate after the elimination of the metastatic lesions. Surgical resection in combination with chemotherapy and radiotherapy leads to improved patients’ survival as well as to prolonged disease-free interval until the occurrence of secondary lesions.

 

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