The data regarding prevalence and clinical characteristics of DDC among Israeli Arabs are confusing. The aim was to investigate the prevalence and clinical feature of DDC among Israelis Arabs in compression with Israelis Jewish's in a retrospective cohort observational study. All subjects who underwent screening colonoscopy within two years were included. Data were extracted from the patient charts included demographic, anthropometric measurement, underlying diseases, and data regarding the diverticular disease including: location, size, number, and distribution pattern. Overall 3782 screening colonoscopies were performed between April 2014 and April 2016, 474 cases with DDC were diagnosed (12.5%). The prevalence was 8.1% among Arabs and 21.5% among Jewish (P<0.05). The mean age of Arabs was 72.5 ± 5.2 versus 67.1.5 ± 9.5 among Jewish (P<0.001), active smoking was reported in 46.5% among Arabs vs 26% among Jewish(P0.001), pan-diverticulosis was more common among Arabs 42% vs 27% (P0.046), in both groups the disease was male predominant 74% vs 65% (P0.016).From the logistic regression analysis, older age >60(OR 2.14; 95% CI, 1.71-2.93), male sex(OR 1.59; 95% CI, 1.02-2.68), current smoking(OR 2.07; 95% CI, 2.17-2.79), diabetes mellitus(OR 1.67; 95% CI, 1.51-1.76), dyslipidemia(OR 1.52; 95% CI, 1.15-1.82), BMI >23kg/m2(OR 1.23; 95% CI, 1.05-1.72), hypothyroidism (OR 1.62; 95% CI, 1.13-1.56) and hypertension(OR 1.43; 95% CI, 1.02-2.68) were associated with increased risk for DDC. The prevalence of DDC among Israeli Arabs is low compared with Jewish populations living in Israel. The Arabs DDC patients seem to be older and the DDC tend to be diffuse (pandiverticulosis).