Diabetes mellitus (DM) is now a pandemic non-communicable disease that needs emergency multifactorial interventions. Blood glucose metabolism is normally controlled by a feedback mechanism including islet beta cells, insulin sensitive cells and tissue sensitive to the insulin have higher magnitude of beta cell response. Based on various etiology and pathogenesis, there are many type of diabetes with similar symptoms and manifestations. However, diabetic-hyperglyacemia appears difficult to control within the normal range of glycaemic level and no lasting solution to this disease. Since after the discovery of standard medication for DM such as oral hypoglycaemic agents and insulin other, numerous therapeutic and technological advances have improved the lives of patients with DM. Moreover, based on the clinical trials and future focus, many antidiabetic agents and methods of good glycaemic control were found that can positively affect or normalized glucose metabolism. The decision to use any of this techniques is based on its efficacy, safety and patient factors. This article reviewed the recent therapeutic and technological advances and the future trends in the management of DM with a view to obtain possible final solution to the management of this disease.
 

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