The UNICEF Conceptual Framework (2013) shows that disease is one of the direct causes of malnutrition in children under five. The therapeutic itinerary plays a role in the prognosis of the disease, and in turn, affects the incidence of malnutrition in an individual. The data used in this article comes from the survey on the determinants of malnutrition in children under five in the department of Mayo Danay in the Far North of Cameroon. A cross-sectional, descriptive study was conducted on a cluster sample at two levels random sampling design was used. Anthropometric measurements were used to assess the nutritional status of children. The study in 295 households, with 433 children shows that the most recurrent diseases in households of malnourished children (acute form; stunting and underweight) are malaria; respiratory infection and diarrhea. The therapeutic itinerary taken by the parents of malnourished children (the three forms) are mainly health Facilities and self-medication. To reduce malnutrition in the study area, we recommend monitoring community-based surveillance for malaria, respiratory infection, diarrhea and promoting health facility attendance.