The coronavirus pandemic has affected many people since its discovery in December 2019. The easiest mode of contracting the virus and the increase in the death rate has resulted in scientists finding an everlasting remedy to control the situation. In the current study, the general knowledge of Ghanaians on the COVID-19 pandemic was examined. Again, the study analysed if Ghanaians support the use of herbal medicines as effective to treat the pandemic. A survey generated with google form was used to gather the views of 104 participants. A Principal Component Factor Analysis (PCFA) grouped the variables into four components: preventive measures, herbal medicines, awareness, and treatment. People’s general knowledge of the pandemic reported preventive measures as the highest, followed by awareness and treatment. While Ghanaians recognise the use of herbal medicines as effective in boosting the immune system to fight many diseases, including the COVID-19, they disagree with the submission that herbal medicines are more effective than drugs for treating the coronavirus. The study recommends a thorough clinical investigation in the use of herbal remedies and conventional drugs to determine the effectiveness of treating the pandemic.