Herbal extracts contain multiple biologically active chemicals, and indigenous medicinal plants have been used traditionally as a major source of drugs for the treatment of various illnesses, including osteoarthritis (OA). The concerns about side effects associated with conventional arthritis therapies have sparked a renewed scientific interest in traditional natural anti-arthritis remedies. Current study was performed to find out the potential beneficial effect of the originally compounded herbal tea “Arthrocon” on the damaged articular cartilage in equine naturally occurring OA using some markers of altered joint metabolism. The results suggest that the four monthsphytotherapy with herbal tea “Arthrocon” is clinically relevant for treatment of osteoarthritis in horses by its ability to reduce joint inflammation and the articular cartilage destruction.