Medical University, Plovdiv consists of four faculties and one Medical College. The medical activities performed in order to protect the citizens’ life and health in case of natural and man-made disasters were part of students’ educational programs from the University foundation in 1945. The medical science development and the recorded increase in disasters frequency and severity, as well as the public expectations, in last decades have had significant impact on Disaster Medicine teaching. The aim of this publication is to present the objective and challenges of Disaster Medicine education in Medical University, Plovdiv. By the means of descriptive method, the objectives of the established Disaster Medicine program in the Medical University, Plovdiv are described. Comparative method was applied in order to analyze how the theoretical and practical exercises during students’ education respond to Disasters’ Medical Management and Support. As a result of performed analyses the advantages of established educational program, as well as the ways for its improvement are presented.