This study is carried out in Khartoum state to investigate the effect of chemotherapy and radiotherapy on thyroid hormones. The patients were divided into two groups; group one patients were treated with the chemotherapy and radiotherapy for short period of time (two months) and group two patients were treated with chemotherapy and radiotherapy for long period of time (one year), to evaluate the effect of chemotherapy and radiotherapy on thyroid gland, and to study the prevalence of cancers in Sudanese patients. The results revealed no significant difference (P > 0.05) between the two groups in thyroid hormones; Triiodothyronine (T3), Thyroxine (T4) and Thyroid-stimulating hormone (TSH). Moreover, the study found that the highest prevalence of cancer was found in breast cancer 22.7%, second higher prevalence of cancer were found in oral cancer and intestine cancer 11.4%. In the meantime, the study found that women more susceptible to cancer than men 63.6% & 36.4% respectively.
 

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