Methods for eliminating Helicobacter pylori infection are often chosen on the basis of strength, on the basis of regional antimicrobial patterns, local recommendations, and drug availability. Health care providers should consult their patients about any use of antibiotics prior to or exposure, and consider that information before choosing the type of treatment. The objective of this study is to determine the comparison of treatment preference’s for H.pylori eradication, sequential therapy versus hybrid therapy. The study design was Quasi experimental comparative study. The place and duration of study is Shiekh Zayed university Teaching hospital Khost Afghanistan from June 2020 to March 2021. A Quasi experimental comparative study of patients visiting the Medicine Department was carried out by accessing the patient’s peptic ulcer diseases and gastritis. All patients from 16 years to 80 years of age irrespective of their sex, suffering from some peptic ulcer diseases and gastritis problem were included in the study while those who presented for follow-up, Immune-compromised patients, getting anti-cancer treatment were excluded from the study. The data was analyzed by SPSS version 25. Patients with peptic ulcer disease and gastritis diagnosed with H. positive pylori were included for study. Hybrid Treatment group received amoxicillin (1 g bid) and omeprazole (20 mg bid) for 7 days followed by clarithromycin (500 mg bid), and metronidazole (400 mg tid), for the next 7 days. The Sequential Treatment group receiving omeprazole and amoxicillin for 5 days followed by omeprazole, metronidazole and clarithromycin for the next 5 days. Problems, completion rate, compliance of both group were compared. For comparison the treatment preferences CHI Square test evaluation was used. Details have been updated by SPSS version 25. Hybrid treatment show less complications as compared to sequential treatment, i.e 3:9. Among 145 patients the 156 (41.1%) were Male and 224 (58.9%) were Female. The eradication rate of H. pylori in peptic ulcer disease patients treated with ST and HT was 83.0% versus 86.8% (P = 0.021) by per protocol analysis. By modified INTENTION TO TREAT, the eradication rate was (P = 0.031), and by intention to treat analysis it was 67% versus 92.1%. Hybrid therapy achieves the highest rate of elimination of H.pylori as compared to sequential therapies.
 

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