Since the early period of the pandemic, the regions most affected by the pandemic, apart from China were the United States, Spain, Italy, Germany and France. However, early scientific analytical reports predicted that Africa was going to have the worse hit. The aim of the study was to explain the reason for the low rate of spread and virulence of the SARS-CoV2 Virus in Africa. The result showed that the more hygienic world worries more about Non-Communicable diseases, Africa still has a high burden of communicable diseases. Due to the nature of our hygiene and prevalent communicable diseases, we have been exposed to a lot of microbes, some of which have low virulence, but due to antigenicity, it confers some type of amnestic immunity. The Indigenous African immune system, especially the innate immunity has been modified above that of the western countries and this can be attributed to the nature of the hygiene and vaccines practiced in most African countries
 

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