This study aimed at the identification, isolation and determination of antibiogram of Klebsiella pneumoniae isolates from other pathogens in sputum samples of hospitalized adults in five primary healthcare centers (PHCs) in parts of Edo North district - Nigeria over a period of twelve (12) months. K. pneumoniae has become one of the common causes of infections in hospitalized individuals with the emergence of multi-drug resistant strains particularly those involved in nosocomial diseases. A total number of 70 pathogens were isolated from the 500 samples collected. Out of the 70 pathogens, 31(44.3%) were Klebsiella pneumoniae. K. pneumoniae was identified by standard microbiological techniques and API20E. Statistically analysis was based on p<0.05, the isolation rate was higher in males (54.8%) than females (45.2%) and in 20-29yrs old subjects (35.5%), there was no statistically significance of K. pneumonia occurrence among the different sex at p>0.05 (p=0.306) or age group p=0.141. Antibiotic susceptibility testing was done by Kirby-Bauer disc diffusion method and interpreted as per CLSI guidelines. High level susceptibility of Klebsiella pneumonia was observed with levofloxacin (100%), (96.8%) to imipenem, (93.5%) to ciprofloxacin and gentamicin (87.1%). Isolates showed high intermediate resistance to Streptomycin (35.5%), high antibiotic resistance to ampicillin (80.6%), amoxicillin (74.2%) and streptomycin (64.5%) was reported. The present study reveals the frequency of isolation of Klebsiella from sputum samples and their tendency towards antibiotic resistance. The data from this study reveals the incidence of klebsiella pneumoniae strains in hospitalized patients and their tendency towards antibiotic resistance.
 

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