Ganoderma lucidum, is a mushroom used for alternative medicine worldwide particularly in China, also known as “Immortality Mushroom”. Traditional medicines usually contain a single active compound, and it is well-known that this single-compound has been found to be efficient and safe in preclinical models and several animal studies. The present study aimed to investigate the effects of Ganoderma lucidum (Red Reishi mushroom) on female genital system histologically by light microscopy. 40 female Sprague-Dawley rats weighing 200-250g were used in the experiments. Study animals were divided into 4 groups as control, Ganoderma lucidum, Ganoderma lucidum + vitamine C, and vitamine C groups. The results of the present study revealed no unfavorable effects of Ganoderma lucidum on rat female genital system at that dose and duration of exposure.

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