A significant step during infection is the attachment of pathogen with the host cell surface. Mycobacterium tuberculosis is a major human pathogenic strain that invades host cell by using several successful mechanisms. FnBPs are important protein present on microorganism which specifically binds with the Fn protein of host. Antigen85 complex and PE_PGRS family shows fibronectin binding properties that has evidenced important role in many bacterial adherence including species of mycobacterium. FnBPs plays a vital role in adhesion with the host surface as well as in various signalling pathway.
 

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